About
Who and what is POLYNEURON?

Polyneuron is a pharmaceutical spin-off of the University of Basel founded in late 2014, building on excellent expertise in carbohydrate-based drug discovery and clinical neurology. The company’s Antibody-Catch™ technology platform enables the chemical design of injectable glycopolymers. These glycopolymers are designed to selectively eliminate autoantibodies in autoimmune disease patients, while leaving the immune system intact.

This pioneering therapeutic approach holds great potential for effective and safe treatments for antibody-mediated autoimmune diseases. Polyneuron’s platform focus in on rare but devastating autoimmune diseases of the nervous system with an unmet medical need and where the pathological role of anti-carbohydrate autoantibodies is well established.

With funding of about CHF 5 million to date, Polyneuron delivered a preclinical proof of principle with its main asset PN-1007 for the treatment of anti-MAG neuropathy and obtained the orphan drug designation from the European Medicines Agency. In addition, the basis could be laid for a promising pipeline – the Antibody-Catch™ technology platform has a broad applicability scope and can be used to target carbohydrate-binding proteins in the broadest sense. Polyneuron strives to make Antibody-Catch™ a clinical reality and hopes to make a difference in the lives of people suffering from devastating diseases.

 

Products
Paradigm shifts in autoimmune diseases

The Antibody-Catch™ platform technology enables the development of biodegradable and injectable glycopolymers for highly specific interception of autoimmune disease antibodies. We are currently focusing on autoimmune diseases of the peripheral nervous system that involve autoantibodies against carbohydrate epitopes.

Get in touch
Contact information

Polyneuron Pharmaceuticals AG
c/o Basel Inkubator
Hochbergerstrasse 60C
CH-4057 Basel

eMail: info@polyneuron.com

Technology

Concept
How does “Antibody-Catch™” work?

Antibody-Catch™ is a platform technology developed by Polyneuron for the treatment of antibody-mediated autoimmune diseases. It facilitates the rational design of drugs that bind and block disease-causing autoantibodies. The platform-derived drugs are biodegradable high-molecular weight glycopolymers that offer multiple epitope-mimics to the autoantibodies. As a result, the drug serves as a decoy for the autoantibody, which gets sequestered and eliminated from the body. This highly specific treatment approach is fundamentally new and could potentially enable treatment options for previously incurable diseases.

Polyneuron currently focuses on autoimmune diseases which involve autoantibodies against carbohydrate epitopes.

Pipeline

The drugs that are derived from the Antibody-Catch™ platform hold great potential for a specific and especially safe immunotherapy. This is achieved by designing glycopolymer drugs, which are of low immunogenicity due to their carbohydrate nature. Polyneuron has extensive know-how in carbohydrate-based drug discovery and currently focuses to employ the Antibody-Catch™ technology for autoimmune diseases which involve autoantibodies against carbohydrate epitopes.

Preclinical

  • Identi­fication

  • Optimi­zation

  • Safety & Manu­facturing

Pre-ind

  • Review

  • Approval

Clinical

  • Phase 1

  • Phase 2

  • Phase 3

Anti-MAG neuropathy

PN-1007

Multifocal motor neuropathy

PN-1018

ABO-incompatible organ & stem cell transplantation

PN-032 & PN-056

IgA nephropathy

Lead identification

Effective and selective
PN-1007 for the treatment of anti-MAG neuropathy

PN-1007 was designed to target the IgM autoantibodies that cause anti-MAG neuropathy. It mimics the natural HNK-1 carbohydrate epitope and strongly binds to the disease-causing antibodies in vitro. Thus, it blocks autoantibody-binding to the natural HNK-1 epitope on MAG at very low concentrations. In vivo the drug efficiently eliminates circulating anti-MAG antibodies. In 2017, promising in vivo proof of principle data has been published in the renowned journal PNAS. Polyneuron has already obtained the orphan drug designation from the European Medicines Agency for PN-1007 in anti-MAG neuropathy. CMC for PN-1007 has been stablished to major extent and clinical trial-enabling safety studies are ongoing. Treatment with PN-1007 would be the first antigen-specific therapy for anti-MAG neuropathy and therefore can be expected to be much more effective and selective in its mode of action compared to current unspecific immunosuppressive treatments for the disease, which are used off-label. PN-1007 may protect myelin sheaths in patients by eliminating the pathogenic antibodies and thus potentially even enable myelin restoration.

Preventing binding events
PN-1018 for treatment of multifocal motor neuropathy (MMN)

PN-1018 is being developed for the treatment of multifocal motor neuropathy (MMN). PN-1018 presents multiple mimics of the natural GM1 carbohydrate epitope that is attacked by affinity-matured anti-GM1 autoantibodies in patients suffering from MMN. Thus it acts as a scavenger for the pathogenic antibodies. To date we have shown, that PN-1018 glyopolymers can efficiently block the binding of pathogenic anti-GM1 autoantibodies of neuropathy patients to GM1 in vitro. Further in vitro and in vivo evaluation of PN-1018 has been initiated. PN-1018 has the potential to eliminate anti-GM1 autoantibodies in patients suffering from MMN and may preserve the motor nerves by blocking antibody-mediated as well as complement-mediated pathogenic anti-GM1 antibody effects.

Convenient application
PN-032 & PN-056 for ABO-incompatible transplantation

 

PN-032 & PN-056 are developed for the selective in vivo depletion of isoagglutinin antibodies (anti-A and anti-B blood group antibodies). The A and B antigens are carbohydrate structures which are present on hematopoietic cells, endothelia, and many other tissues. The antibodies against these carbohydrate antigens present a key hurdle for organ and stem cell transplantations with ABO-blood group incompatibility. The ABO hurdle can be overcome by depletion of isoagglutinin antibodies which is nowadays achieved with multiple extracorporeal plasmapheresis or immunoadsorption cycles. These treatments are very cumbersome and time-consuming for the patients. In some cases, immunosuppressive treatment is used to suppress the production of isoagglutinin antibodies. Our compounds PN-032 & PN-056 can be conveniently administered as injectables. These compounds selectively bind and remove the isoagglutinin antibodies and furthermore potentially induce a down-regulation of isoagglutinin production, which would provide an additional benefit for the patients and potentially promote the survival of the transplant.

Company

Getting things done
Executive Team

  • Ruben Herrendorff

    Dr. Ruben Herrendorff CEO

    Ruben is a co-founder and Chief Executive Officer of Polyneuron. Since the company inception Ruben was substantially responsible for the raising of CHF 5m for Polyneuron, including a CHF 3.1m seed financing round, for the setup of a highly motivated core team, and for delivering on key company objectives. Polyneuron’s success has been recognized by several start-up prices and grants. Ruben holds an M.Sc. and Ph.D. in Pharmaceutical Sciences from the University of Basel. During his time at University he specialized on drug discovery for neuromuscular orphan diseases and was co-inventor of the Antibody-Catch™ technology and Polyneuron’s most advanced asset PN-1007.

  • Pascal Hänggi

    Dr. Pascal Hänggi CSO

    Pascal is a co-founder and Chief Scientific Officer at Polyneuron. He is responsible for the company’s research & development activities as well as regulatory affairs. Since the company foundation Pascal was instrumental in delivering on key company milestones in preclinical drug development, the management of contract research activities, and the interaction with health authorities. He holds a M.Sc. in Pharmaceutical Sciences from the University of Basel and completed his Ph.D. at the University of Zürich in Molecular Medicine. During this time he specialized on hematological diseases. Importantly, he then laid the scientific foundation for a promising novel treatment of a hematological orphan disorder and was also involved in the setup of a clinical trial.

  • Michael Wacker

    Dr. Michael Wacker CBO

    Michael joined Polyneuron in January 2018. Since then he is responsible for the company’s business development activities as Chief Business Officer. He furthermore supports the executive team in financing and drug development aspects. He also serves as a member of Polyneuron's board. Michael has more than fifteen years’ experience in life science industry, including biotech. He is a board member of various life science companies. Most recently, he was Chief Scientific Officer and member of the Board of Directors of GlycoVaxyn, a company that he co-founded in 2004 and was acquired by GSK in February 2015 for USD 212m. He holds a M.Sc. in Biochemistry from the ETHZ and completed his Ph.D. and post-doctoral fellowship in Microbiology at ETHZ. During this time he was an inventor of the GlycoVaxyn technology.

Strategic muscle
Board of Directors

  • Gerhard Müller

    Dr. Gerhard Müller Chairman

    Dr. Gerhard Müller (Chairman) joined Polyneuron's board in February 2018. He is an experienced drug hunter who has successfully managed research units and led drug discovery projects within the pharmaceutical, the CRO, and the biotech industry. Currently he serves as the Chief Scientific Officer at the New York-based biotech company Gotham Therapeutics. Over the last 6 years, Gerhard has successfully established from scratch the medicinal chemistry business unit at Mercachem, a Dutch Chemistry CRO. Prior to that, he held CSO and Vice President positions at Proteros Fragments, GPC Biotech, and Axxima Pharmaceuticals. Gerhard began his industry career at Glaxo in Verona, followed by project management positions at Bayer AG in Leverkusen, and was head of medicinal chemistry at Organon in the Netherlands. He holds a PhD in organic chemistry obtained from the Technical University of Munich, where he discovered anti-adhesive integrin antagonists under the supervision of Prof. Dr. Horst Kessler.

  • Prof. Beat Ernst

    Prof. Beat Ernst Board member

    Prof. Ernst is a co-founder of Polyneuron and member of the board. He was Head of the Institute of Molecular Pharmacy at the University of Basel for many years. He is a renowned expert in the synthesis and pharmacological evaluation of carbohydrate-based drugs. Prof. Ernst has an extensive track record in drug discovery. Rivipansel (GMI-1070), a compound invented by Prof. Ernst in collaboration with GlycoMimetics, has demonstrated clinical proof-of-concept as a treatment for vaso-occlusive crises in patients with sickle cell anemia. Rivipansel was licensed by GlycoMimetics to Pfizer and entered Phase 3 under FDA Special Protocol Assessment in June, 2015. Furthermore, Prof. Ernst was substantially involved in development of Polyneuron's Antibody-Catch™ technology and its main asset PN-1007.

  • Werner Enz

    Dr. med. Werner Enz Board member

    Dr. med. Werner M. Enz is Chief Executive Officer of ErfindungsVerwertung AG (EVA), the Basel Life Science start-up agency, and CEO of the Basel Inkubator. He holds a Doctorate in Medicine from the University of Bern, Switzerland, and an MBA with specialization in strategy from Edinburgh Business School, Scotland, UK. During his career, Dr. Enz worked for several innovative startups and mid-sized B2B technology companies in life science, leading late stage clinical and business development as well as commercial operations, including as country manager and CEO. He also held various senior executive positions with Roche in Basel, Canada and Germany, including running Roche’s largest business unit in oncology, immunology and transplant medicine. After a merger project with Rhône Poulenc Rorer (today Sanofi) in Sweden, he worked for Abbott International as Commercial Director Europe in the USA and Divisional Head Hospital business in Switzerland.

  • Michael Wacker

    Dr. Michael Wacker CBO

    Michael joined Polyneuron in January 2018. Since then he is responsible for the company’s business development activities as Chief Business Officer. He furthermore supports the executive team in financing and drug development aspects. He also serves as a member of Polyneuron's board. Michael has more than fifteen years’ experience in life science industry, including biotech. He is a board member of various life science companies. Most recently, he was Chief Scientific Officer and member of the Board of Directors of GlycoVaxyn, a company that he co-founded in 2004 and was acquired by GSK in February 2015 for USD 212m. He holds a M.Sc. in Biochemistry from the ETHZ and completed his Ph.D. and post-doctoral fellowship in Microbiology at ETHZ. During this time he was an inventor of the GlycoVaxyn technology.

Scientific excellence
Scientific Advisory Board

  • Prof. Beat Ernst

    Prof. Beat Ernst Board member

    Prof. Ernst is a co-founder of Polyneuron and member of the board. He was Head of the Institute of Molecular Pharmacy at the University of Basel for many years. He is a renowned expert in the synthesis and pharmacological evaluation of carbohydrate-based drugs. Prof. Ernst has an extensive track record in drug discovery. Rivipansel (GMI-1070), a compound invented by Prof. Ernst in collaboration with GlycoMimetics, has demonstrated clinical proof-of-concept as a treatment for vaso-occlusive crises in patients with sickle cell anemia. Rivipansel was licensed by GlycoMimetics to Pfizer and entered Phase 3 under FDA Special Protocol Assessment in June, 2015. Furthermore, Prof. Ernst was substantially involved in development of Polyneuron's Antibody-Catch™ technology and its main asset PN-1007.

  • Prof. Andreas J. Steck

    Prof. Dr. med. Andreas J. Steck Medical

    Prof. Steck is a co-founder of Polyneuron. Previously, he was head of the Neurology Clinic of the University Hospital Basel from 1993 to 2007. He is a highly respected medical expert in the field of neurological diseases, in particular in the area of immune-mediated neuropathies. He also held various prestigious positions such as President of the Swiss Neurological Society and President of the European Neurological Society. With his neurology know-how and valuable clinical network Prof. Steck supports Polyneuron particularly with respect to the clinical development of PN-1007.

  • Jochen Kinter

    Dr. Jochen Kinter Neurobiology

    Jochen Kinter is a senior researcher in the neuromuscular research group at the University Hospital of Basel. He is a biochemist/neurobiologist by training and has gained extensive know-how in the field of molecular mechanisms of neurological and neuromuscular diseases. He has worked in the area of immune-mediated neuropathies as well as multiple sclerosis and is supporting Polyneuron with his expertise.

  • Rudolf Duthaler

    Dr. Rudolf Duthaler CMC

    Dr. Rudolf Duthaler studied chemistry at the ETH-Zürich. After a postdoctoral stay at the California Institute of Technology he was for 6 years leading a research group at the ETH. In 1986 he moved to Basel – Central Research Laboratories of Ciba-Geigy – , where he was involved in diverse projects ranging from technical applications to synthetic methodology and biologically active molecules for pharmaceuticals and crop protection. After the merger with Sandoz he entered the pharmaceutical research of Novartis in the area of autoimmune diseases, transplantation and inflammation. He was involved in the development of a polymeric injectable drug GAS914, designed for the removal of natural antibodies directed against carbohydrate antigens, the first line of defense in xenotransplantation. With this expertise he supports Polyneuron in CMC aspects.